Types of Substances

Desired effects

The effects many people look for from stimulants are:

• feeling euphoric or very happy
• having more energy
• feeling more confident
• having more sex drive
• feeling more pleasure with sex
• being able to stay awake
• feeling “disinhibited” or confident, powerful and energetic
• losing weight
• finishing or staying focused on school or work

(Note: ADHD medication can have the opposite effect of traditional stimulants when used correctly. They can make people diagnosed with ADHD feel calmer and more focused).

Signs of being high or intoxicated

Stimulants can make people feel high. Stimulant intoxication happens when a stimulant drug makes a person’s reactions heightened or exaggerated. They may seem to have bigger reactions than usual, like being more aware (hyperaware). They may be more sexual (hypersexual) and more alert to possible threats (hypervigilant). They may also feel restless and anxious and move a lot without meaning to (psychomotor agitation).

Overdose or drug poisoning

Signs of overdose can include:

• having a very high body temperature (hyperthermia)
• seeing or hearing things that aren’t there (becoming paranoid or psychotic) or hallucinating
• having seizures, sweats, bad headaches
• needing to urinate (pee) more often
• feeling anxious and agitated

Overamping is used to describe overdosing on speed or cocaine. It can happen regardless of the amount the person takes or how long they’ve been using the drug. In other words, there isn’t really a set amount of a drug that can cause an overdose. It can result from many things like:

• not sleeping
• being exhausted from not having enough to eat or drink
• being with people who make you feel uncomfortable
• having taken too many hits

Stimulant toxicity is a condition that can happen when you take stimulants. It is a medical emergency and is life-threatening. It may cause organ damage, seizures, heart attack, stroke, kidney failure, etc.

While the effects of overdosing on cocaine are similar to what happens with speed (amphetamine), coke (cocaine) is more likely to cause strokes, heart attacks, and seizures.

Withdrawal symptoms

Withdrawal is what happens when you stop using substances suddenly after you’ve been using them regularly. It’s important to remember that withdrawal symptoms are the opposite of the high you feel when using the substance. The withdrawal symptoms for stimulants include an excessive need for sleep and an increase in appetite and cravings. People also often have little energy and feel depressed.

Harm reduction tips

Tips to reduce harm when using stimulants include:

• use less
• use at safe injection sites
• use clean needles and supplies or gear
• get your drugs tested to see if they are mixed with other contaminants such as fentanyl or dangerous chemicals

For general safety tips, see The Basics section.

For more information on vaping, check out the following links: Vaping and the Myths and Facts of Vaping and Tobacco.

Benzodiazepines or benzos, such as Xanax and Valium, are sedatives or tranquilizers. They are sometimes prescribed to relax tight muscles, treat alcohol withdrawal, or manage seizures. They are also used to sedate people before surgery or dental procedures. Some people may be using benzos for insomnia or anxiety, even though they are no longer the recommended first treatment option.

Overdose or drug poisoning

Benzos can be dangerous when mixed with other drugs like methadone (opioids). Signs of overdose include extreme sedation and a type of amnesia that won’t let you form new memories (anterograde amnesia). It is safe to use benzos when they are prescribed for you and used only occasionally or for short periods of time.

Like any drug, benzos can become addictive if they are used more regularly. A person may start to crave the drug or need to take a higher dose as their tolerance increases (they need more and more of the drug to have the same effect).

Withdrawal symptoms

If you use benzos regularly and then stop suddenly, you may have withdrawal symptoms. These can include headaches, insomnia, difficulty concentrating, tremors and loss of appetite. If you stop using benzos after regular use of high doses, you may experience seizures, delirium (confused thinking), agitation or paranoia (like believing you are being threatened when you aren’t).

GHB is sometimes referred to as Gina, G, or Tina (when it is mixed with crystal meth). It is a powerful sedative that can cause someone to become unconscious or go into a deep sleep. It can be very dangerous and lead to death when taken with alcohol or other drugs. In the 1990s, GHB was referred to as a “club drug” and more recently as a “date rape drug,” referring to incidents when it has been secretly slipped into peoples’ drinks so they became unconscious and not able to remember or resist a sexual assault.

Overdose or drug poisoning

With GHB, there is only a small difference between a dose that produces a wanted effect and a dose that causes an overdose. A little too much of this drug can be fatal. Combining GHB with alcohol or other drugs increases the risk of overdose and other dangerous effects, including death.

Withdrawal symptoms

GHB is addictive and can lead to tolerance and physical dependence. Physical dependence is when your body needs the drug in order to feel normal, think clearly and stop withdrawal symptoms. You can go into withdrawal if you stop using the drug suddenly. Withdrawal symptoms can include anxiety, tremors, an inability to sleep and other unpleasant, dangerous effects, including paranoia with hallucinations and high blood pressure.

Ways to reduce harm depend on what kind of downer the person is taking. For general safety tips, see The Basics section.

For alcohol:

• Avoid drinking on an empty stomach. Eat food and drink water before and while you are drinking alcohol
• Avoid drinking games that may cause you to consume a large amount of alcohol in a short period of time
• Try switching every second drink for something non-alcoholic, like pop, kombucha or a mocktail
• Don’t drink if you are using medication that interacts with alcohol (check out drugcocktails.ca for more information)

For benzos:

Don’t mix with other downers. “Benzo dope” (opioids mixed with non-prescribed benzodiazepines) in unregulated street drugs have been discovered to contain a lethal combination of opioids and benzos.

For GHB:

Don’t use alone. Begin with a tiny test amount before taking more. Do not take GHB with alcohol or other drugs.

Overdose or drug poisoning

Opioids change the way people experience pain. They slow down breathing, heart rate, thoughts and actions. If a person takes more than their body can handle (tolerate), they may stop responding and become unconscious. An overdose can lead to death because the drug interferes with the parts of the brain that are responsible for breathing.

It is difficult to say how much of a drug can cause an overdose. It depends on many things, like which drug, how much and how often. It is affected by what your body is used to (level of tolerance).

Overdoses are often caused by:

• taking large doses often
• injecting the drug
• taking an opioid while also using sleeping pills, benzos or muscle relaxants
• using when you also have other health conditions (breathing difficulties, kidney or liver disease)

To learn more, there is more information on how to recognize and respond to an overdose.

Withdrawal symptoms

Withdrawal symptoms with opioid use include nausea, headaches, nervousness, anxiety and irritability. People often experience alternating chills, goosebumps and muscle pain. They become obsessed with getting the drug.

Harm reduction tips

Harm reduction tips for opioids include:

• not using alone
• having a naloxone kit on hand and understanding how to use it
• not mixing with alcohol or other drugs
• taking a small amount first to see how strong it is

The chance of overdose depends on which drug it is, and how much the person has taken. Cannabis hyperemesis syndrome is a rare condition that can occur in people who use cannabis daily over a long period. It can cause severe vomiting, as well as other symptoms like nausea and stomach or abdominal pain.

The use of cannabis has been linked to psychotic symptoms or psychosis for a small number of people. Psychosis may be thought of as a break with reality. Symptoms include experiencing thoughts, feelings, sounds or seeing things (hallucinations) that others around you do not experience. It becomes difficult to know what is real and what is not. For most people, these symptoms go away as the drug wears off after several hours, and their thinking, feeling and perception return to normal. The symptoms do not usually return unless cannabis is used again. But, you are at high risk of more serious problems if you have a family member with psychosis or schizophrenia, and especially if you also develop a temporary psychosis when using cannabis. It is very important to talk with a healthcare provider about your use if you are at risk.

Overdose is more likely with dissociative hallucinogens. For example, large amounts of PCP can lead to coma, seizures and death. Regardless of the type of hallucinogen, a risk for overdose is produced by the drugs’ effect on people’s judgment and mood. For example, people on psychedelics may lose their sense of reality and make risky decisions, which may cause them to do things they wouldn’t normally do. Doing things they wouldn’t normally do can create opportunities for these drugs to place people in situations which may put their lives at risk. Psychedelics can also be poisonous when mixed with contaminants, such as other drugs.

Harm reduction tips

For harm reduction tips to avoid overdose and other severe symptoms, see safety tips in The Basics section.